NORMAL-TENSION GLAUCOMATOUS OPTIC NEUROPATHY IS RELATED TO BLOOD PRESSURE VARIABILITY IN THE MARACAIBO AGING STUDY

Hypoperfusion of the optic nerve might be involved in pathogenesis normal-tension glaucomatous neuropathy (GON). Mean arterial pressure (MAP) drives ocular perfusion, but no previous studies have addressed risk GON relation to blood (BP) variability, independent BP level. In a cross-sectional study, 93 residents Maracaibo, Venezuela, underwent optical coherence tomography, visual field assessments and 24-h ambulatory monitoring between 2011 2016. We investigated association with or without defects reading-to reading variability MAP, as captured by MAP level (VIMmap). Odds ratios (ORs) were adjusted for propensity score up five factors. Among participants (87.1% women; mean age, 61.9 years), 26 had open-angle at both eyes; 14 defects; 19 did not defects. The OR GON, expressed per 1-SD increment VIMmap (2 mm Hg), 2.17 (95% confidence interval, 1.33–3.53) unadjusted; 2.20 (1.35–3.61) only; 1.93 (1.10–3.41) additional adjustment educational attainment, high-density lipoprotein (HDL) cholesterol office hypertension; 1.95 (1.10–3.45) models including intraocular pressure. confirmed our priori hypothesis that most likely operating via hypoperfusion nerve, is associated GON. 24-H therefore help stratify